Concerns about composite reference standards in diagnostic research

Value of composite reference standards in diagnostic research.

A common challenge in diagnostic studies is to obtain a correct final diagnosis in all participants. Ideally, a single error-free reference test, known as a gold standard, is used to determine the final diagnosis and estimate the accuracy of the test or diagnostic model under evaluation. If the reference standard does not perfectly correspond to true target disease status, estimates of the accu...

Research about before Research with Standards

Evaluating diagnostic accuracy in the face of multiple reference standards.

A universal challenge in studies that quantify the accuracy of diagnostic tests is establishing whether each participant has the disease of interest. Ideally, the same preferred reference standard would be used for all participants; however, for practical or ethical reasons, alternative reference standards that are often less accurate are frequently used instead. The use of different reference ...

Utility of composite reference standards and latent class analysis in evaluating the clinical accuracy of diagnostic tests for pertussis.

Numerous evaluations of the clinical sensitivity and specificity of PCR and serologic assays for Bordetella pertussis have been hampered by the low sensitivity of culture, the gold standard test, which leads to biased accuracy estimates. The bias can be reduced by using statistical approaches such as the composite reference standard (CRS) (e.g., positive if culture or serology positive; negativ...

Standards for Reporting Qualitative Research

سخن سردبیر Editorial مجله دانشگاه علوم پزشکی رفسنجان دوره هجدهم، آذر 1398، 860-859       استاندارد‌هایی برای گزارش پژوهش‌‌های کیفی Standards for Reporting Qualitative Research     محسن رضائیان[1]   M. Rezaeian   تاکنون در مجله علمی دانشگاه، مقالات گوناگونی در خصوص استاندارد‌های تدوین شده برای گزارش شفاف پژوهش‌های کمّی و از جمله کارآزمایی‌‌های بالینی [1] و مطالعات مشاهده‌ای اپیدمیو...